Description

2'-Deoxy-4'-Thiocytidine is a chemically modified nucleoside analog where the oxygen atom in the furanose ring's 4'-position is replaced by sulfur. This structural modification is of significant interest in medicinal chemistry and biochemistry for the development of novel antiviral and anticancer agents. It serves as a critical building block for oligonucleotide synthesis and is utilized in advanced research exploring nucleic acid structure, function, and therapeutic applications. Key industries requiring this high-purity intermediate include pharmaceutical R&D, biotechnology, and academic research institutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used as a modified building block (phosphoramidite) for incorporating thio-sugar modifications into DNA/RNA strands to alter stability and binding properties.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of nucleic acids and enzyme-substrate interactions.
• Antisense & siRNA Development: A component in the design of therapeutic oligonucleotides with enhanced nuclease resistance and pharmacokinetic profiles.
• Mechanistic Probes: Utilized to study metabolic pathways of nucleosides and the function of kinases and other nucleic acid-processing enzymes.

Basic Information

Product Name	2'-Deoxy-4'-Thiocytidine
CAS No.	134111-30-1
Molecular Formula	C9H13N3O3S
Molecular Weight	243.28 g/mol
Synonyms	4'-Thio-2'-deoxycytidine; 4'-Thiodideoxycytidine; 1-(4-Thio-2-deoxy-β-D-erythro-pentofuranosyl)cytosine; 2'-Deoxy-4'-thiocytidine; 4'-S-2'-Deoxycytidine; d4SC; 4'-Thio-dC
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-4'-Thiocytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.