Description

cis-[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-4-Methylbenzenesulphonate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the production of potent antifungal agents, particularly those belonging to the azole class. It is essential for pharmaceutical R&D and active pharmaceutical ingredient (API) manufacturing sectors, where precise chemical structure and purity are critical for efficacy and regulatory approval.

Application

• Primary Intermediate for Antifungal APIs: Critical synthesis block for azole-based antifungal drugs such as bifonazole and related analogues.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new antifungal candidates.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturers for the scalable production of antifungal medications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Chemical Synthesis Studies: Utilized in academic and industrial labs to study structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	cis-[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-4-Methylbenzenesulphonate
CAS No.	134071-44-6
Molecular Formula	C21H20Cl2N2O5S
Molecular Weight	479.37 g/mol
Synonyms	Bifonazole Intermediate; cis-1-[(4-Methylphenyl)sulfonyl]oxy-2-[(2,4-dichlorophenyl)(1H-imidazol-1-yl)methyl]-1,3-dioxolane; 4-Methylbenzenesulfonic Acid cis-[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl Ester; (cis)-4-[[(4-Methylphenyl)sulfonyl]oxymethyl]-2-[(2,4-dichlorophenyl)(1H-imidazol-1-yl)methyl]-1,3-dioxolane; 1,3-Dioxolane-4-methanol, 2-[(2,4-dichlorophenyl)(1H-imidazol-1-yl)methyl]-, 4-methylbenzenesulfonate (ester), cis-
EINECS	Contact for details

Quality Control

Our cis-[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-4-Methylbenzenesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.