Description

1H-1,2,4-Triazole-1-Carbonylchloride,3-Chloro-4,5-Dihydro-4-Methyl-5-Oxo-(9Ci) is a specialized heterocyclic building block and reactive intermediate of significant interest in advanced organic synthesis. Its value lies in its dual functionality, combining a reactive acid chloride group with a substituted triazole core, enabling its use in constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel triazole-containing drug candidates, particularly in antiviral, antifungal, and anticancer research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and plant growth regulators that leverage the triazole pharmacophore.
• Material Science: Serves as a precursor for creating functional polymers, ligands for metal-organic frameworks (MOFs), or specialty coatings with tailored properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation, labeling biomolecules, or developing activity-based probes.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed or other cross-coupling methodologies to form carbon-heteroatom bonds.
• Peptide Mimetics & Macrocycle Synthesis: Facilitates the introduction of the triazole ring, often used as a bioisostere, into peptide backbones or cyclic compounds.

Basic Information

Product Name	1H-1,2,4-Triazole-1-Carbonylchloride,3-Chloro-4,5-Dihydro-4-Methyl-5-Oxo-(9Ci)
CAS No.	134048-17-2
Molecular Formula	C5H5Cl2N3O2
Molecular Weight	210.02 g/mol
Synonyms	3-Chloro-4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazole-1-carbonyl chloride; 3-Chloro-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carbonyl chloride; 1-Carbonylchloride-3-chloro-4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazole; 1H-1,2,4-Triazole-1-carbonyl chloride, 3-chloro-4,5-dihydro-4-methyl-5-oxo-; 3-Chloro-4-methyl-δ2-1,2,4-triazoline-5-one-1-carbonyl chloride. Contact for additional trade names or registry numbers.
EINECS	Contact for details

Quality Control

Our production of 1H-1,2,4-Triazole-1-Carbonylchloride,3-Chloro-4,5-Dihydro-4-Methyl-5-Oxo-(9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic workflows. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.