Description

2'-Demethylbenanomicin A is a structurally defined ansamycin antibiotic derivative, recognized for its potent biological activity and utility as a key reference standard and research compound. Its significance lies in its role as a critical intermediate and tool for studying antibiotic mechanisms, structure-activity relationships, and microbial resistance. This high-purity compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on novel antibiotic discovery and development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in antibiotic production.
• Antibiotic Research & Development: Serves as a crucial intermediate or lead compound in the synthesis and evaluation of new ansamycin-class antibiotics.
• Biochemical Studies: Employed in in vitro assays to investigate mechanisms of action against bacterial targets, such as RNA polymerase inhibition.
• Microbiology Research: Utilized in academic and industrial labs to study bacterial growth inhibition and resistance patterns.
• Metabolite Identification: Acts as a standard in LC-MS and HPLC analyses for identifying and quantifying related metabolites in biological samples.
• Process Chemistry: Used in the development and scaling of synthetic routes for complex antibiotic molecules.

Basic Information

Product Name	2'-Demethylbenanomicin A
CAS No.	133806-63-0
Molecular Formula	C₄₇H₆₆N₂O₁₂
Molecular Weight	875.0 g/mol
Synonyms	2'-Demethylbenanomycin A; Demethylbenanomicin A; Benanomicin A, 2'-demethyl-; Antibiotic K252a analog; Ansamycin antibiotic derivative; (2S)-2-[(1S,3R,4S,5R,8S,9S,12S,13R,14S,15R,16E,18E,20R,21R,24S)-21-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-5,8,13,14,15-pentahydroxy-4,9,12-trimethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,10-dioxo-1,11-dioxacyclotetracos-16,18-dien-24-yl]-2-hydroxypropanoic acid
EINECS	Contact for details

Quality Control

Our 2'-Demethylbenanomicin A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.