Description

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol is a high-purity, stereochemically defined triazole derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its unique molecular architecture, which is essential for constructing complex molecules with specific three-dimensional orientations, a key requirement in modern pharmaceutical development. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel antifungal and other bioactive agents, where precise stereochemistry directly impacts biological activity and efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel triazole-based antifungal pharmaceuticals.
• Antifungal Agent Synthesis: Serves as a precursor in the synthesis pathway for advanced systemic antifungal compounds targeting fungal CYP51.
• Asymmetric Synthesis: Utilized as a building block in stereoselective chemical reactions to introduce complex chiral centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Process Chemistry: Used in the scale-up and optimization of manufacturing routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol
CAS No.	133775-25-4
Molecular Formula	C₁₂H₁₃F₂N₃O₂
Molecular Weight	269.25 g/mol
Synonyms	(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol; (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol; Voriconazole Related Compound B; UK-109496 Impurity B; (2R,3R)-Voriconazole Diol; (2R,3R)-2,4-Difluoro-α-(1H-1,2,4-triazol-1-ylmethyl)benzenepropanol; (2R,3R)-1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1,3-butanediol
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for analytical method validation, ensuring data integrity and reliability for regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (2R,3R)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.