Description

2'-o-Allylguanosine is a chemically modified nucleoside derivative, specifically an allyl-protected analog of guanosine. This compound is a critical building block in oligonucleotide synthesis, particularly for the development of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity intermediates for advanced nucleic acid chemistry and drug discovery programs.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific RNA sequences.
• siRNA and miRNA Research: Serves as a modified monomer to enhance the stability, specificity, and delivery of small interfering RNA (siRNA) and microRNA (miRNA) constructs.
• Pharmaceutical Intermediates: An important raw material in the manufacture of nucleotide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: The allyl group provides a handle for further chemical modifications, such as fluorescent labeling or attachment to delivery vehicles.
• Academic and Industrial R&D: Utilized in life science research for studying nucleic acid structure, function, and for developing novel therapeutic modalities.

Basic Information

Product Name	2'-o-Allylguanosine
CAS No.	133766-28-6
Molecular Formula	C13H17N5O5
Molecular Weight	323.31 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3-Allyloxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 2'-O-Allylguanosine; Guanosine, 2'-O-allyl-; 2'-Allyloxyguanosine; N2-Isobutyryl-2'-O-allyl-5'-O-(4,4'-dimethoxytrityl)guanosine (protected form precursor); Allyl Guanosine Derivative; 2'-O-(2-Propenyl)guanosine
EINECS	Contact for details

Quality Control

Our 2'-o-Allylguanosine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for pharmaceutical and biotech applications. Each batch is tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or cGMP needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.