Description

2'-o-Allyladenosine is a chemically modified nucleoside analog, specifically an adenosine derivative with an allyl group at the 2'-oxygen position of the ribose sugar. This modification is critical for imparting unique biochemical properties, making it a valuable intermediate in advanced pharmaceutical and life science research. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, oligonucleotide synthesis, and medicinal chemistry for developing novel therapeutics and diagnostic probes.

Application

• Oligonucleotide Synthesis: Key building block (phosphoramidite) for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & RNAi Therapeutics: Used to create chemically modified oligonucleotides with enhanced stability and binding affinity for therapeutic applications.
• Medicinal Chemistry Research: Serves as a crucial intermediate in the development of nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Probes: Enables the study of RNA structure, function, and protein-RNA interactions through site-specific labeling.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor for enzymes involved in nucleotide metabolism and modification.
• Cross-linking Agent Development: The reactive allyl group can be utilized for creating cross-linked nucleic acid structures or conjugates.

Basic Information

Product Name	2'-o-Allyladenosine
CAS No.	133766-26-4
Molecular Formula	C13H17N5O4
Molecular Weight	307.31 g/mol
Synonyms	2'-O-Allyladenosine; Adenosine, 2'-O-allyl-; 9-[(2R,3R,4R,5R)-3-Allyloxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurine; 2'-O-(2-Propenyl)adenosine; N6-Amino-9-(2-O-allyl-β-D-ribofuranosyl)purine; Allyl Adenosine Derivative; Modified Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our 2'-o-Allyladenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports applications in GMP-grade pharmaceutical development and high-precision research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.