Description

4-(2-Hydroxyethoxy)Retinoic Acid is a synthetic derivative of retinoic acid, a key molecule in cellular signaling and differentiation. This compound matters for its enhanced solubility and modified biological activity profile compared to its parent molecule, making it a valuable intermediate in advanced pharmaceutical research. It is primarily needed by R&D scientists and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, particularly in dermatology and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel retinoid-based drugs targeting skin conditions and cancers.
• Biochemical Research: Used as a ligand or probe in studies of nuclear receptor (RAR/RXR) signaling pathways and gene expression regulation.
• Dermatological R&D: Investigated for the development of next-generation topical treatments for acne, psoriasis, and photoaging due to its modified retinoid activity.
• Oncology Research: Employed in preclinical studies exploring retinoids' role in cell differentiation, proliferation, and apoptosis for cancer therapy.
• Cosmeceutical Actives Development: Serves as a precursor for advanced anti-aging and skin-repair active ingredients.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-(2-Hydroxyethoxy)Retinoic Acid
CAS No.	133697-07-1
Molecular Formula	C22H32O4
Molecular Weight	360.49 g/mol
Synonyms	4-(2-Hydroxyethoxy)retinoic acid; 4-(2-Hydroxyethoxy)-all-trans-retinoic acid; 4-(2-Hydroxyethoxy)tretinoin; 4-Hydroxyethoxyretinoic Acid; 4-HER; Retinoic acid, 4-(2-hydroxyethoxy)-; 4-(β-Hydroxyethoxy)retinoic acid; 4-(2-Hydroxyethoxy)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
EINECS	Contact for details

Quality Control

Our 4-(2-Hydroxyethoxy)Retinoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.