Description

Galiellalactone CAS NO 133613-71-5 is a potent and selective fungal metabolite and natural product known for its unique sesquiterpene lactone structure. This compound is of significant interest in pharmaceutical and biochemical research due to its role as a specific inhibitor of STAT3 signaling, a pathway implicated in various cancers and inflammatory diseases. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology, immunology, and signal transduction pathway studies.

Application

• Pharmaceutical Research & Development: Serves as a critical STAT3 signaling pathway inhibitor for investigating novel cancer therapeutics and anti-inflammatory agents.
• Biochemical Assay Standard: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in assay development and validation.
• Academic Research: A key tool compound for studying cell proliferation, apoptosis, and cytokine signaling in university and institutional labs.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) libraries to identify and validate new drug candidates targeting transcription factors.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy and mechanism of action for potential oncology treatments.

Basic Information

Product Name	Galiellalactone
CAS No.	133613-71-5
Molecular Formula	C15H20O3
Molecular Weight	248.32 g/mol
Synonyms	(3aR,4S,7aR)-4-Hydroxy-7a-methyl-3a,4,5,6,7,7a-hexahydro-1H-indene-1,6(2H)-dione; Galiellalactone; STAT3 Inhibitor, Galiellalactone; (3aR,4S,7aR)-4-Hydroxy-7a-methyl-3a,4,5,6,7,7a-hexahydroisobenzofuran-1(3H)-one
EINECS	Contact for details

Quality Control

Our Galiellalactone is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere when appropriate. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.