Description

1-(Trimethylsilyl)-3-Fluoro-4-Methoxybenzene is a high-purity organosilicon intermediate featuring a unique combination of silyl protection, fluorine substitution, and a methoxy group. This compound matters for its role in facilitating complex synthetic pathways, particularly in the development of advanced materials and active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides where the trimethylsilyl group acts as a protective moiety.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions (e.g., Suzuki, Stille) where the silyl group can be utilized or transformed.
• Organic Synthesis Reagent: Functions as a versatile reagent for introducing protected phenolic functionalities into complex molecules under mild conditions.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on aromatic systems in academic and industrial R&D settings.

Basic Information

Item	Details
Product Name	1-(Trimethylsilyl)-3-Fluoro-4-Methoxybenzene
CAS No.	133595-06-9
Molecular Formula	C10H15FOSi
Molecular Weight	198.31 g/mol
Synonyms	3-Fluoro-4-methoxy-1-(trimethylsilyl)benzene; 1-Fluoro-2-methoxy-5-(trimethylsilyl)benzene; (3-Fluoro-4-methoxyphenyl)trimethylsilane; Trimethyl(3-fluoro-4-methoxyphenyl)silane; 3-Fluoro-4-methoxybenzene, 1-(trimethylsilyl)-; 133595-06-9; TMS-protected 3-fluoro-4-methoxyphenol
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3-Fluoro-4-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.