Description

5'-o-(Dimethoxytrityl)-O6-Phenyl-2'-Deoxyinosine is a high-purity, protected nucleoside derivative, a critical building block in oligonucleotide synthesis. Its primary value lies in enabling the precise, automated assembly of DNA and RNA sequences for research and therapeutic applications. This compound is essential for pharmaceutical R&D, biotechnology companies, and academic laboratories focused on antisense technology, siRNA, aptamer development, and diagnostic probe manufacturing.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used in the production of research-grade and therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probe Development: Enables the creation of labeled probes for PCR, FISH, and microarray technologies.
• Aptamer Research: Serves as a modified nucleotide in SELEX processes to develop high-affinity binding molecules.
• Structural Biology Studies: Incorporated into oligonucleotides to study nucleic acid structure, function, and protein interactions.
• Synthetic Biology: A building block for constructing novel genetic circuits and engineered biological systems.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-O6-Phenyl-2'-Deoxyinosine
CAS No.	133471-08-6
Molecular Formula	C38H36N4O6
Molecular Weight	644.72 g/mol
Synonyms	5'-O-DMT-O6-Phenyl-2'-deoxyinosine; 5'-O-(4,4'-Dimethoxytrityl)-O6-phenyl-2'-deoxyinosine; DMT-O6-Ph-dI; O6-Phenyl-2'-deoxyinosine, 5'-O-(4,4'-dimethoxytrityl)-; 2'-Deoxy-O6-phenylinosine 5'-O-(4,4'-dimethoxytrityl) ether; N6-Phenyl-2'-deoxyadenosine DMT-protected (common misnomer); Protected Deoxyinosine Derivative; DMT-O6-Ph-dI Phosphoramidite precursor
EINECS	Contact for details

Quality Control

Our 5'-o-(Dimethoxytrityl)-O6-Phenyl-2'-Deoxyinosine is manufactured under strict quality systems to ensure consistency and reliability for sensitive synthesis workflows. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.