Description

5-Thiazolecarbonyl Chloride, 4-(Chloromethyl)-2-Methyl- (9Ci) is a highly reactive and versatile heterocyclic building block, specifically a functionalized thiazole derivative. This compound is critical for the synthesis of complex molecules, enabling the introduction of both a reactive acyl chloride and a chloromethyl group in a single step. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the thiazole core is a common bioactive motif.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of functional polymers and organic electronic materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: An essential building block for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	5-Thiazolecarbonyl Chloride, 4-(Chloromethyl)-2-Methyl- (9Ci)
CAS No.	133386-00-2
Molecular Formula	C6H5Cl2NOS
Molecular Weight	210.08 g/mol
Synonyms	4-(Chloromethyl)-2-methyl-1,3-thiazole-5-carbonyl chloride; 2-Methyl-4-(chloromethyl)thiazole-5-carbonyl chloride; 4-Chloromethyl-2-methylthiazole-5-carbonyl chloride; 2-Methyl-4-chloromethylthiazole-5-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 5-Thiazolecarbonyl Chloride, 4-(Chloromethyl)-2-Methyl- (9Ci) adheres to stringent internal quality protocols to ensure batch-to-batch consistency and reliability for your synthetic workflows. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place. Due to its hygroscopic and reactive nature, this material should be kept under an inert atmosphere (e.g., nitrogen or argon) and protected from moisture. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.