Description

Adenosine 5'-Phosphor(Adamantyl)Amidate is a chemically modified nucleotide analog designed for advanced biochemical and pharmaceutical research. This compound is a crucial building block in the synthesis of stabilized oligonucleotides, offering enhanced resistance to enzymatic degradation. It is primarily utilized by researchers and manufacturers in the fields of antisense therapy, diagnostic probe development, and medicinal chemistry for creating novel therapeutic agents.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite monomer for constructing nuclease-resistant therapeutic oligonucleotides.
• Diagnostic Probe Development: Used in the creation of stable, high-affinity probes for nucleic acid detection and in-situ hybridization.
• Medicinal Chemistry & Drug Discovery: Serves as a critical intermediate in the development of nucleotide-based pharmaceuticals targeting various diseases.
• Bioconjugation and Labeling: The adamantyl group provides a handle for further functionalization and conjugation with delivery vehicles or reporter molecules.
• Basic Biochemical Research: Employed in studies investigating RNA interference (RNAi), gene expression, and nucleic acid structure-function relationships.

Basic Information

Item	Detail
Product Name	Adenosine 5'-Phosphor(Adamantyl)Amidate
CAS No.	133310-22-2
Molecular Formula	C20H29N6O5P
Molecular Weight	464.46 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dA(Bz) Phosphoramidite (Adamantyl); 2'-Deoxyadenosine, N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Adenosine, 2'-deoxy-N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(2-cyanoethyl diisopropylphosphoramidite); DNA Phosphoramidite Monomer (dA-Bz); Adamantyl-protected dA Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of Adenosine 5'-Phosphor(Adamantyl)Amidate is manufactured and tested under strict quality systems. We guarantee high purity suitable for oligonucleotide synthesis and provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and moisture content. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen). This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC/MS, NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.