Description

1-Methyl-4-(Trimethylsilyl) Imidazole is a versatile organosilicon-protected imidazole derivative, valued for its role as a key synthetic intermediate and protecting group reagent. Its primary commercial significance lies in its ability to impart silyl group functionality, which is crucial for modifying reactivity and solubility in advanced organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing imidazole or modified heterocyclic cores.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators where the trimethylsilyl group aids in specific chemical transformations.
• Organometallic Catalyst Ligand: Acts as a precursor or ligand in catalytic systems for cross-coupling and other transition metal-catalyzed reactions.
• Silylating Agent: Employed to introduce the trimethylsilyl (TMS) protecting group onto sensitive functional groups (like hydroxyl or amine) during multi-step synthetic sequences.
• Material Science Research: Utilized in the development of novel ionic liquids, conductive polymers, and other functional organic materials.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-Methyl-4-(Trimethylsilyl) Imidazole
CAS No.	133227-93-7
Molecular Formula	C7H14N2Si
Molecular Weight	154.29 g/mol
Synonyms	4-(Trimethylsilyl)-1-methylimidazole; 1-Methyl-4-(trimethylsilyl)-1H-imidazole; 1-Methyl-4-trimethylsilylimidazole; N-Methyl-4-(trimethylsilyl)imidazole; 1H-Imidazole, 1-methyl-4-(trimethylsilyl)-; TMS-Protected N-Methylimidazole
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(Trimethylsilyl) Imidazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.