Description

12-(Acetyloxy)-3,6,7-Trihydroxycholan-24-Oic Acid Methyl Ester is a high-purity, semi-synthetic bile acid derivative with significant value as a key pharmaceutical intermediate. This compound is crucial for researchers and manufacturers developing advanced therapeutic agents, particularly in the fields of hepatology and metabolic disease. It is primarily sought by the pharmaceutical, biotechnology, and fine chemical synthesis industries for the production of novel drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel bile acid analogs and hepatoprotective agents.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Metabolic Research: Serves as a key reagent in biochemical studies investigating bile acid metabolism, liver function, and related pathways.
• Drug Discovery: Employed in medicinal chemistry programs for the design and synthesis of new chemical entities targeting nuclear receptors like FXR.
• Fine Chemical Synthesis: Used as a specialized starting material or intermediate in multi-step synthetic routes for complex organic molecules.

Basic Information

Product Name	12-(Acetyloxy)-3,6,7-Trihydroxycholan-24-Oic Acid Methyl Ester
CAS No.	133181-57-4
Molecular Formula	C₂₇H₄₄O₇
Molecular Weight	480.64 g/mol
Synonyms	Methyl 12-acetoxy-3,6,7-trihydroxy-5β-cholan-24-oate; 12-Acetoxy-3,6,7-trihydroxycholanic Acid Methyl Ester; 3α,6α,7α-Trihydroxy-12α-acetoxy-5β-cholan-24-oic Acid Methyl Ester; Methyl 3α,6α,7α-trihydroxy-12α-acetoxy-5β-cholan-24-oate; 12α-Acetoxy-3α,6α,7α-trihydroxy-5β-cholan-24-oic Acid Methyl Ester; Chenodeoxycholic Acid 12-Acetate Methyl Ester Derivative
EINECS	Contact for details

Quality Control

Our 12-(Acetyloxy)-3,6,7-Trihydroxycholan-24-Oic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Single Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.