Description

6-Glucopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate is a sophisticated nucleoside phosphate derivative, a key building block in advanced biochemical research and pharmaceutical development. This compound matters for its role as a modified nucleotide analog, enabling the study and manipulation of nucleic acid structure and function. It is primarily needed by researchers and manufacturers in the fields of antiviral drug discovery, oligonucleotide synthesis, and medicinal chemistry, where precise molecular tools are essential for innovation.

Application

• Antiviral Drug Development: Serves as a crucial intermediate in the synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or precursor for incorporating specific functionalities into synthetic DNA/RNA strands for therapeutic and diagnostic applications.
• Biochemical Probes: Acts as a substrate or inhibitor in enzymatic studies to investigate polymerase activity, DNA repair mechanisms, and other nucleic acid-related pathways.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies aimed at developing new therapeutics targeting viral and genetic diseases.
• Labeled Nucleotide Production: A precursor for creating azide-labeled nucleotides, which are used in bioorthogonal chemistry for imaging and tracking within biological systems.

Basic Information

Product Name	6-Glucopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate
CAS No.	133101-34-5
Molecular Formula	C16H22N5O12P
Molecular Weight	507.35 g/mol
Synonyms	3'-Azido-3'-deoxy-5'-thymidinyl 6-glucopyranosyl phosphate; 3'-Azido-3'-deoxythymidine 5'-(6-glucopyranosyl phosphate); AZT 5'-(6-Glucopyranosyl Phosphate); 5'-O-[(6-O-Phosphono-β-D-glucopyranosyl)]-3'-azido-3'-deoxythymidine; Thymidine, 3'-azido-3'-deoxy-, 5'-(dihydrogen phosphate), 6-(β-D-glucopyranosyl) ester; AZT Glucopyranosyl Phosphate; Nucleoside Phosphate Sugar Conjugate
EINECS	Contact for details

Quality Control

Our 6-Glucopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.