Description

3,N(4)-Etheno-3'-Deoxyguanosine Monophosphate is a chemically modified nucleotide analog, a key intermediate in the study of DNA adducts and mutagenesis. This compound is critical for researchers investigating the mechanisms of carcinogenesis and the structural impact of etheno adducts on nucleic acid stability and function. It is primarily utilized by academic research institutions, pharmaceutical R&D laboratories, and diagnostic kit manufacturers focused on molecular biology, toxicology, and biomarker discovery.

Application

• Biochemical Research: Used as a standard or reference material in studies of DNA damage, repair mechanisms, and mutagenic pathways.
• Analytical Standard: Serves as a high-purity calibrant in Liquid Chromatography-Mass Spectrometry (LC-MS) and HPLC methods for quantifying DNA adducts in biological samples.
• Pharmaceutical Development: Employed in the research and development of novel therapeutics targeting specific DNA lesions or repair enzymes.
• Diagnostic Assay Development: Integral for developing sensitive assays and kits designed to detect etheno-DNA adducts as biomarkers of oxidative stress and exposure.
• Toxicology Studies: Applied in in vitro and in vivo models to assess the genotoxic effects of various chemical agents and environmental toxins.

Basic Information

Product Name	3,N(4)-Etheno-3'-Deoxyguanosine Monophosphate
CAS No.	133073-61-7
Molecular Formula	C12H14N5O7P
Molecular Weight	371.24 g/mol
Synonyms	1,N2-Etheno-2'-deoxyguanosine 5'-monophosphate; 3,N4-Etheno-2'-deoxyguanosine 5'-monophosphate; 1,N2-Etheno-dGMP; εdGMP; Etheno-dGMP; 3,N4-α-Etheno-2'-deoxyguanosine-5'-monophosphate; 1,N2-Etheno-2'-deoxyguanosine-5'-monophosphate
EINECS	Contact for details

Quality Control

Our 3,N(4)-Etheno-3'-Deoxyguanosine Monophosphate is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is subjected to comprehensive analytical testing including HPLC purity analysis, NMR, and mass spectrometry for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.