Description

(3R,4S)-2-Oxo-4-Phenylazetidin-3-Yl Acetate is a high-purity chiral β-lactam building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for the production of novel antibiotics and other pharmacologically active molecules, enabling precise stereochemical control. It is primarily needed by pharmaceutical R&D departments, fine chemical manufacturers, and academic research institutions focused on developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of carbapenem and other β-lactam antibiotics.
• Organic Synthesis Building Block: Used in the construction of complex molecules requiring the 3-acetoxyazetidin-2-one scaffold.
• Medicinal Chemistry Research: Serves as a precursor for structure-activity relationship (SAR) studies in drug discovery programs.
• Asymmetric Synthesis: Utilized in reactions where the defined (3R,4S) stereochemistry is essential for biological activity.
• Process Chemistry Development: Employed in scaling up routes to active pharmaceutical ingredients (APIs) with high enantiomeric purity.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(3R,4S)-2-Oxo-4-Phenylazetidin-3-Yl Acetate
CAS No.	133066-59-8
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(3R,4S)-3-Acetoxy-4-phenylazetidin-2-one; (3R-cis)-3-(Acetyloxy)-4-phenyl-2-azetidinone; 4-Phenyl-3-acetoxy-2-azetidinone; β-Lactam Acetate Derivative; trans-3-Acetoxy-4-phenylazetidin-2-one; (3R,4S)-4-Phenyl-3-acetoxyazetidin-2-one; Azetidin-2-one, 3-(acetyloxy)-4-phenyl-, (3R,4S)-
EINECS	Contact for details

Quality Control

Our (3R,4S)-2-Oxo-4-Phenylazetidin-3-Yl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity determination, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.