Description

β-D-Lyxofuranose, 5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-1,2-o-(1-Methylethylidene)- is a high-purity, protected carbohydrate intermediate essential for advanced organic synthesis. This compound is specifically engineered to provide a stable, reactive handle for the selective functionalization of the sugar backbone, enabling the construction of complex nucleoside analogs and other bioactive molecules. It is a critical building block for pharmaceutical research and development, particularly in antiviral and anticancer drug discovery programs.

Application

• Nucleoside & Nucleotide Synthesis: A key protected intermediate for the preparation of modified nucleosides used in antiviral and anticancer therapeutics.
• Carbohydrate Chemistry: Serves as a versatile building block for the synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediates: Used in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially those targeting viral polymerases.
• Chemical Biology Probes: Enables the creation of labeled or modified sugars for studying biological recognition and metabolic pathways.
• Process Chemistry Development: Provides a scalable, well-defined starting material for optimizing synthetic routes in pilot and commercial-scale manufacturing.

Basic Information

Product Name	β-D-Lyxofuranose, 5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-1,2-o-(1-Methylethylidene)-
CAS No.	133048-89-2
Molecular Formula	C24H32O5Si
Molecular Weight	428.60 g/mol
Synonyms	1,2-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-β-D-lyxofuranose; 5-O-(tert-Butyldiphenylsilyl)-1,2-O-isopropylidene-β-D-lyxofuranose; tert-Butyldiphenylsilyl 1,2-O-isopropylidene-β-D-lyxofuranos-5-yl ether; TBDPS-protected lyxofuranose; β-D-Lyxofuranose, 5-O-[(1,1-dimethylethyl)diphenylsilyl]-1,2-O-(1-methylethylidene)-; Protected D-lyxose derivative
EINECS	Contact for details

Quality Control

Our β-D-Lyxofuranose, 5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-1,2-o-(1-Methylethylidene)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.