Description

4-Chloro-2,5-Difluorobenzoyl Fluoride is a high-value, multi-functional aromatic fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive acyl fluoride group and halogen substituents, makes it a critical intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability, metabolic stability, and binding affinity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving charge transport, thermal stability, and optical properties.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for synthesizing high-performance polymers, such as polyarylates and polyamides, with enhanced chemical and thermal resistance.
• Chemical Research & Development: A versatile reagent for introducing the 4-chloro-2,5-difluorobenzoyl moiety into complex molecular architectures via nucleophilic acyl substitution or cross-coupling reactions.

Basic Information

Product Name	4-Chloro-2,5-Difluorobenzoyl Fluoride
CAS No.	132794-09-3
Molecular Formula	C7H2ClF3O
Molecular Weight	194.54 g/mol
Synonyms	2,5-Difluoro-4-chlorobenzoyl Fluoride; 4-Chloro-2,5-difluorobenzoic acid fluoride; Benzoyl fluoride, 4-chloro-2,5-difluoro-; 4-Chloro-α,α,2,5-tetrafluorotoluene; 4-Chloro-2,5-difluorobenzofluoride; 132794-09-3; 4-Chloro-2,5-difluorobenzoyl fluoride
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2,5-Difluorobenzoyl Fluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and we support custom purity grades (e.g., >98%, >99%) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.