Description

5-Bromo-2''-Deoxy-2'',2''-Difluorouridine is a modified nucleoside analog, a key advanced pharmaceutical intermediate (API) in the synthesis of novel antiviral and anticancer therapeutics. Its precise molecular structure, featuring bromine and difluoro modifications, is engineered to enhance metabolic stability and target specificity in drug candidates. This high-purity building block is essential for research and development in pharmaceutical chemistry, particularly for organizations developing next-generation nucleotide-based drugs targeting viral polymerases and specific cellular enzymes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antiviral and anticancer prodrugs.
• Antiviral Drug Development: Used in research targeting Hepatitis C Virus (HCV), HIV, and other viral infections by acting as a nucleotide analog.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that inhibit DNA/RNA synthesis in rapidly dividing cells.
• Biochemical Research: Utilized in enzymatic studies and as a substrate analog to investigate polymerase mechanisms and inhibition.
• Prodrug Synthesis: A key starting material for creating more bioavailable and targeted prodrug forms of active nucleotide metabolites.
• Labeled Compound Synthesis: Can be used to create isotopically labeled versions for pharmacokinetic and metabolic tracing studies.

Basic Information

Product Name	5-Bromo-2''-Deoxy-2'',2''-Difluorouridine
CAS No.	132786-35-7
Molecular Formula	C9H10BrF2N2O5
Molecular Weight	341.09 g/mol
Synonyms	5-Bromo-2'-deoxy-2',2'-difluorouridine; 5-Br-dFdU; 5-Bromo-2',2'-difluoro-2'-deoxyuridine; 5-Bromo-gemcitabine intermediate; 2'-Deoxy-2',2'-difluoro-5-bromouridine; 5-Bromo-2'-deoxy-2',2'-difluorouri-dine; 5-Bromo-dFdUrd; BR-DU
EINECS	Contact for details

Quality Control

Our 5-Bromo-2''-Deoxy-2'',2''-Difluorouridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.