Description

Purine-9-β-D-(3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro)Arabinoriboside is a sophisticated nucleoside analog derivative, specifically designed as a key synthetic intermediate. This compound matters for its critical role in the development of novel antiviral and anticancer therapeutics, particularly within the field of modified oligonucleotides. Pharmaceutical researchers and fine chemical manufacturers need this high-purity building block to advance drug discovery programs targeting RNA-based diseases.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Antiviral Pro-drug Synthesis: Used in the research and development of prodrugs targeting viral polymerases.
• Oligonucleotide Chemistry: Serves as a protected, fluorinated monomer for solid-phase synthesis of therapeutic oligonucleotides (e.g., antisense, siRNA).
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and function.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Reference Standard: Used as a high-purity analytical standard for quality control in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	Purine-9-β-D-(3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro)Arabinoriboside
CAS No.	132723-01-4
Molecular Formula	C24H21FN4O6
Molecular Weight	480.45 g/mol
Synonyms	2'-Deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosylpurine; 2'-Fluoro-2'-deoxy-3',5'-di-O-benzoyl-β-D-arabinofuranosylpurine; 9-[(2-Deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-arabinofuranosyl)]purine; 2'-F-ara-Purine 3',5'-dibenzoate; β-D-2'-Fluoro-2'-deoxy-3',5'-di-O-benzoyl-arabinofuranosyl purine; Protected 2'-F-araA; 2'-F-araA 3',5'-dibenzoate
EINECS	Contact for details

Quality Control

Our Purine-9-β-D-(3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro)Arabinoriboside is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.