Description

N2-Phenylacetyl Guanosine is a chemically modified nucleoside derivative where a phenylacetyl group is attached to the N2 position of the guanine base. This modification is critical for imparting specific biochemical properties, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside analog prodrugs and antiviral compounds.
• Antiviral Research: Used in the development of potential therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a precursor for investigational anticancer agents that interfere with DNA/RNA synthesis in tumor cells.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate the function of purine-processing enzymes.
• Labeled Compound Synthesis: A starting material for creating isotopically labeled (e.g., 13C, 15N) guanosine derivatives for metabolic tracing and pharmacokinetic studies.
• Oligonucleotide Modification: Used to introduce specific functional groups into synthetic oligonucleotides for diagnostic or therapeutic applications.

Basic Information

Product Name	N2-Phenylacetyl Guanosine
CAS No.	132628-16-1
Molecular Formula	C18H19N5O6
Molecular Weight	401.38 g/mol
Synonyms	Guanosine, N2-(phenylacetyl)-; N-(Phenylacetyl)guanosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(phenylacetamido)-1,9-dihydro-6H-purin-6-one; 2-(Phenylacetamido)guanosine; N2-Phenylacetylguanosine; Phenylacetyl Guanosine; N2-PAG
EINECS	Contact for details

Quality Control

Our N2-Phenylacetyl Guanosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.