Description

1,N(6)-Propanodeoxyadenosine is a chemically modified nucleoside analog, specifically a deoxyadenosine derivative with a propanoyl group at the N6 position. This structural modification is of significant interest in medicinal chemistry and biochemical research for the development of novel therapeutic agents and molecular probes. It serves as a critical building block and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on nucleoside-based drug discovery, oligonucleotide synthesis, and enzyme inhibition studies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate adenosine deaminase and other nucleoside-modifying enzymes.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite building block for the solid-phase synthesis of oligonucleotides with tailored properties.
• Proteomics & Molecular Biology: Employed in the development of affinity probes and chemical tools for studying protein-nucleic acid interactions.
• Diagnostic Reagent Development: Utilized in the formulation of specialized reagents and kits for diagnostic assays.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research in nucleic acid chemistry and drug metabolism.

Basic Information

Product Name	1,N(6)-Propanodeoxyadenosine
CAS No.	132461-42-8
Molecular Formula	C13H17N5O3
Molecular Weight	291.31 g/mol
Synonyms	N6-Propanoyl-2'-deoxyadenosine; 1,N6-Propanodeoxyadenosine; 2'-Deoxy-N6-propanoyladenosine; N6-Propanoyldeoxyadenosine; Propanoyldeoxyadenosine; dA(N6-pr); 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-N6-propanoyladenine
EINECS	Contact for details

Quality Control

Our 1,N(6)-Propanodeoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.