Description

(R)-Cloperastine is the pharmacologically active enantiomer of the antitussive agent cloperastine, distinguished by its specific stereochemistry at the chiral center. This high-purity chiral building block is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs) targeting the central cough reflex. It is essential for pharmaceutical R&D and production teams focused on advanced respiratory therapeutics, chiral drug synthesis, and process chemistry optimization.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as the key chiral intermediate in the manufacture of enantiopure antitussive medications.
• Pharmaceutical R&D: Crucial for preclinical and clinical studies investigating the efficacy and safety profile of the (R)-enantiomer.
• Chiral Switch Development: Enables the development of single-enantiomer drugs from existing racemic mixtures to improve therapeutic index and reduce side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical laboratories.
• Process Chemistry & Scale-Up: Used in optimizing asymmetric synthesis routes and scaling up production for commercial drug manufacturing.
• Respiratory Drug Formulations: Incorporated into final dosage forms such as tablets, syrups, and capsules for persistent, non-productive cough.

Basic Information

Product Name	(R)-Cloperastine
CAS No.	132301-91-8
Molecular Formula	C20H24ClNO
Molecular Weight	329.87 g/mol
Synonyms	(R)-1-[2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl]piperidine; (R)-Cloperastine; Dexcloperastine; (R)-Cloperastine fendizoate (salt precursor); Fenspiride related compound; Levotuss; Chiral cloperastine; (R)-enantiomer of cloperastine
EINECS	Contact for details

Quality Control

Our (R)-Cloperastine is manufactured under strict quality management systems, targeting purities suitable for pharmaceutical development. Each batch is subjected to comprehensive analytical testing including chiral HPLC to ensure enantiomeric excess (ee) and identity. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, impurities, and chiral purity specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.