Description

(S)-Ropivacaine Hydrochloride Hydrate is the pure S-enantiomer of the long-acting amide-type local anesthetic, ropivacaine, supplied as its hydrochloride salt monohydrate. This high-purity chiral intermediate is critical for pharmaceutical development, offering a distinct pharmacological profile with reduced cardiotoxicity compared to racemic mixtures. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of advanced anesthetic formulations and neurological research.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of enantiomerically pure local anesthetics.
• Pharmaceutical Intermediate in the synthesis of novel, patent-protected anesthetic drugs.
• Neurological Research as a selective sodium channel blocker for in vitro and in vivo studies.
• Analytical Reference Standard for quality control and method development in pharmaceutical laboratories.
• Preclinical Development for toxicity and efficacy profiling of new anesthetic candidates.
• Formulation Development for creating sustained-release or targeted delivery systems.

Basic Information

Product Name	(S)-Ropivacaine Hydrochloride Hydrate
CAS No.	132112-35-7
Molecular Formula	C17H26N2O • HCl • H2O
Molecular Weight	328.87 g/mol (monohydrate)
Synonyms	(S)-(-)-Ropivacaine Hydrochloride Monohydrate; (S)-Ropivacaine HCl Hydrate; (S)-1-Propyl-2',6'-pipecoloxylidide Hydrochloride Monohydrate; (S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Monohydrate; LEVO-Bupivacaine Hydrochloride Hydrate (related); S-(-)-Ropivacaine Hydrochloride Hydrate; Naropin Impurity (S-enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-Ropivacaine Hydrochloride Hydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5% (anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	4.5% - 6.5% (Theoretical for monohydrate: ~5.5%)
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.