Description

3'-Azido-5'-Isocyano-3',5'-Dideoxythymidine is a specialized nucleoside analog derivative, serving as a critical building block in advanced organic synthesis and medicinal chemistry research. Its unique bifunctional structure, featuring both azido and isocyano groups, makes it a versatile intermediate for click chemistry and the development of novel therapeutic agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on antiviral drug discovery, prodrug synthesis, and the creation of targeted molecular probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Click Chemistry Reagent: Utilizes the azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create complex molecular architectures.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation: Enables the site-specific labeling and modification of biomolecules through its reactive functional groups.
• Prodrug Development: Used in designing masked drug forms that are activated under specific biological conditions.
• Chemical Biology Tool: Acts as a probe to study enzyme mechanisms or cellular pathways involving nucleotide metabolism.

Basic Information

Product Name	3'-Azido-5'-Isocyano-3',5'-Dideoxythymidine
CAS No.	132101-32-7
Molecular Formula	C11H12N6O4
Molecular Weight	292.25 g/mol
Synonyms	3'-Azido-5'-isocyano-3',5'-dideoxythymidine; 3'-Azido-5'-isocyano-2',3'-dideoxythymidine; 5'-Isocyano-3'-azido-2',3'-dideoxythymidine; 1-[(2R,4S,5R)-4-Azido-5-(isocyanomethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; AZT Isocyano Derivative; Thymidine, 3'-azido-5'-isocyano-3',5'-dideoxy-
EINECS	Contact for details

Quality Control

Our 3'-Azido-5'-Isocyano-3',5'-Dideoxythymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.