Description

Rilmakalim CAS NO 132014-21-2 is a high-purity potassium channel activator belonging to the benzopyran chemical class. This compound is of significant interest in pharmaceutical research and development due to its role as a vasodilator and cardioprotective agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery, metabolic studies, and the investigation of smooth muscle relaxation mechanisms.

Application

• Cardiovascular Research: Used as a reference standard and active pharmaceutical ingredient (API) in studies targeting hypertension, angina, and ischemic heart disease.
• Pharmacological Studies: Serves as a key tool compound for investigating ATP-sensitive potassium (KATP) channel function and regulation.
• Drug Discovery & Development: Employed in preclinical research for the synthesis and efficacy testing of new cardioprotective and vasodilatory drug candidates.
• Biochemical Assays: Utilized in in vitro and in vivo models to study vascular smooth muscle relaxation and cellular metabolic pathways.
• Reference Standard: Provides a certified high-purity material for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing.

Basic Information

Product Name	Rilmakalim
CAS No.	132014-21-2
Molecular Formula	C17H21N3O3
Molecular Weight	315.37 g/mol
Synonyms	Rilmakalim; BRL 38227; (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile; N-Cyano-N'-(3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-3-yl)-N''-methylguanidine; 6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-3-ol
EINECS	Contact for details

Quality Control

Our Rilmakalim is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.