Description

2',3'-Didehydro-2',3'-Dideoxytiazofurin is a synthetic nucleoside analogue with significant research interest in antiviral and anticancer applications. This compound matters as a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the *de novo* biosynthesis of guanine nucleotides, making it a valuable tool for studying cellular proliferation and viral replication mechanisms. Researchers in pharmaceutical R&D and academic biochemistry require this high-purity chemical for developing novel therapeutic agents and conducting fundamental biochemical studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and screening of novel antiviral and anticancer drug candidates.
• Biochemical Studies: Used as a specific inhibitor of inosine monophosphate dehydrogenase (IMPDH) to investigate nucleotide metabolism, cell cycle regulation, and immune cell function.
• Antiviral Agent Development: Explored for its potential activity against a range of DNA and RNA viruses due to its mechanism of action on nucleotide pools.
• Oncology Research: Investigated for antiproliferative effects in various cancer cell lines, contributing to the understanding of targeted cancer therapies.
• Enzyme Kinetics & Mechanism: Employed in enzymatic assays to study the kinetics and inhibition profile of IMPDH from different sources.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical compounds.

Basic Information

Product Name	2',3'-Didehydro-2',3'-Dideoxytiazofurin
CAS No.	131922-30-0
Molecular Formula	C11H13N3O4S
Molecular Weight	283.30 g/mol
Synonyms	2,3-Didehydro-2,3-dideoxytiazofurin; Tiazofurin Impurity; 4-Carbamoyl-1-((2R,3S,4R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-olate; β-D-Ribofuranoside, 4-carbamoyl-1-((2R,3S,4R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridinium-3-olate; NSC 286193; IMPDH Inhibitor
EINECS	Contact for details

Quality Control

Our 2',3'-Didehydro-2',3'-Dideoxytiazofurin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.