Description

3'-Hydroxy-1,N(6)-Benzetheno-2'-Deoxyadenosine 3'-Phosphate is a chemically modified nucleotide analog, a key building block in advanced biochemical research and pharmaceutical development. This compound is valued for its role in studying DNA damage, repair mechanisms, and as a potential precursor in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in oncology, molecular biology, and nucleotide chemistry.

Application

• Biochemical Research: Used as a critical reagent and standard in studies of DNA adduct formation, oxidative stress, and nucleotide excision repair pathways.
• Pharmaceutical Development: Serves as a synthetic intermediate or a reference compound in the R&D of novel chemotherapeutic agents and targeted cancer therapies.
• Diagnostic Assay Development: Employed in the development and calibration of sensitive assays (e.g., ELISA, LC-MS/MS) for the detection of specific DNA lesions and biomarkers.
• Academic Research: A vital tool for universities and research institutes investigating the molecular mechanisms of carcinogenesis and genotoxicity.
• Standards and Metrology: Used as a certified reference material (CRM) or high-purity standard for quantitative analytical methods in forensic and environmental toxicology.

Basic Information

Product Name	3'-Hydroxy-1,N(6)-Benzetheno-2'-Deoxyadenosine 3'-Phosphate
CAS No.	131759-78-9
Molecular Formula	C₁₇H₁₈N₅O₇P
Molecular Weight	435.33 g/mol
Synonyms	1,N6-Etheno-2'-deoxyadenosine 3'-phosphate, 3'-OH-1,N6-etheno-dA 3'-phosphate; 3'-Hydroxy-1,N6-etheno-2'-deoxyadenosine 3'-phosphate; εdA 3'-phosphate; 1,N6-ε-dA 3'-phosphate; 3'-OH-ε-dA 3'-phosphate; DNA Adduct Standard (εdA-3'-P); 3'-Phospho-3'-deoxy-1,N6-ethenoadenosine
EINECS	Contact for details

Quality Control

Our production of 3'-Hydroxy-1,N(6)-Benzetheno-2'-Deoxyadenosine 3'-Phosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.