Description

Cyclohexanecarbonyl Chloride, 2-Methoxy-, (1R-Cis)- (9Ci) is a high-purity chiral building block and acylating agent of significant interest in advanced organic synthesis. Its defined stereochemistry and reactive acid chloride functionality make it a critical intermediate for constructing complex molecules with precise spatial orientation. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, where specific stereochemistry can enhance efficacy and reduce environmental impact.
• Asymmetric Catalysis Research: Serves as a standard or reagent in methodological studies for developing new asymmetric synthesis and acylation protocols.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require the (1R-cis) stereoisomer framework.
• Peptide & Protein Modification: Acts as an acylating agent for modifying amino acids or peptides to introduce the 2-methoxycyclohexanecarbonyl moiety.
• Material Science: Potential monomer or cross-linking agent in the synthesis of polymers with specific chiral properties for advanced materials.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 2-Methoxy-, (1R-Cis)- (9Ci)
CAS No.	131601-90-6
Molecular Formula	C8H13ClO2
Molecular Weight	176.64 g/mol
Synonyms	(1R,2S)-2-Methoxycyclohexanecarbonyl chloride; (1R-cis)-2-Methoxycyclohexanecarboxylic acid chloride; (-)-cis-2-Methoxycyclohexanecarbonyl chloride; (1R,2S)-2-Methoxy-1-cyclohexanecarbonyl chloride; trans-(-)-2-Methoxycyclohexanecarboxylic acid chloride; L-(-)-2-Methoxycyclohexanecarbonyl chloride; (1R,2S)-2-Methoxycyclohexanoyl chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 2-Methoxy-, (1R-Cis)- is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, suitable for demanding R&D and scale-up processes. Each batch is analyzed via chiral HPLC, NMR, and GC to confirm identity, enantiomeric excess (ee), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee (1R,2S)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.