Description

Dexamethasone 21-(β-Isothiocyanatoethyl)Thioether is a chemically modified derivative of the potent glucocorticoid dexamethasone, designed for advanced research and synthesis applications. This compound is particularly valuable as a key intermediate or a reactive precursor for the development of novel steroid conjugates, such as those used in targeted drug delivery systems or diagnostic probes. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biotechnology companies engaged in the development of steroid-based therapeutics and specialized biochemical tools.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel dexamethasone conjugates and prodrugs.
• Bioconjugation Research: The reactive isothiocyanate group enables covalent attachment to proteins, antibodies, or other biomolecules for targeted therapy research.
• Steroid Receptor Studies: Used in the development of affinity labels or fluorescent probes for studying glucocorticoid receptor interactions and localization.
• Advanced Drug Delivery Systems: Serves as a precursor for creating polymer-drug conjugates or nanoparticle formulations aimed at improving therapeutic efficacy and reducing side effects.
• Diagnostic Agent Development: Potential use in creating radiolabeled or tagged steroids for imaging and diagnostic applications.

Basic Information

Product Name	Dexamethasone 21-(β-Isothiocyanatoethyl)Thioether
CAS No.	131567-23-2
Molecular Formula	C26H32FN2O5S2
Molecular Weight	535.67 g/mol
Synonyms	Dexamethasone 21-[(2-Isothiocyanatoethyl)thio]ether; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-[(2-Isothiocyanatoethyl)thio]ether; Dexamethasone Isothiocyanate Derivative; Dexamethasone-ITC; Dexamethasone 21-(2-Isothiocyanatoethyl sulfide); Dexamethasone 21-(β-Isothiocyanatoethyl) Sulfide
EINECS	Contact for details

Quality Control

Our Dexamethasone 21-(β-Isothiocyanatoethyl)Thioether is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support traceability and regulatory documentation needs for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.