Description

2',3'-Dideoxy-2',3'-Methanocytidine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a valuable scaffold for probing biochemical pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral and anticancer therapeutics, as well as in fundamental studies of nucleic acid chemistry and enzymology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of viral polymerases and cellular DNA/RNA metabolism.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties and therapeutic efficacy.
• Antiviral Agent Development: Investigated for its potential activity against a range of viral targets due to its modified sugar moiety, which can resist enzymatic degradation.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical compounds.

Basic Information

Product Name	2',3'-Dideoxy-2',3'-Methanocytidine
CAS No.	131347-68-7
Molecular Formula	C10H13N3O4
Molecular Weight	239.23 g/mol
Synonyms	2',3'-Dideoxy-2',3'-methanocytidine; 2',3'-Methano-2',3'-dideoxycytidine; 4-Amino-1-[(1R,4S,5R)-4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hex-1-yl]-2(1H)-pyrimidinone; Bicyclo[3.1.0]hexane nucleoside analog; ddMethanoCytidine
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-2',3'-Methanocytidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.