Description

8-Azido-2'-Deoxyadenosine is a chemically modified nucleoside analog featuring an azido group at the 8-position of the adenine base. This compound is a critical building block and probe in biochemical research, enabling click chemistry reactions for labeling and crosslinking studies of nucleic acids. It is primarily utilized by researchers and developers in the fields of bioconjugation, medicinal chemistry, and oligonucleotide synthesis to investigate DNA structure, function, and to develop novel diagnostic tools.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for site-specific labeling of DNA and oligonucleotides via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Medicinal Chemistry Research: Used as a precursor or intermediate in the synthesis of novel nucleoside analogs with potential therapeutic activity.
• Structural Biology Probes: Incorporated into oligonucleotides to study DNA-protein interactions, dynamics, and structural conformations through photo-crosslinking.
• Diagnostic Development: Employed in the creation of labeled probes for detection systems in molecular diagnostics and bioanalytical assays.
• Materials Science: Facilitates the functionalization of surfaces and nanomaterials with DNA for biosensor and nanotechnology applications.
• Antiviral/Anticancer Agent Research: Investigated for its potential biological activity as a modified nucleoside in screening libraries.

Basic Information

Product Name	8-Azido-2'-Deoxyadenosine
CAS No.	131265-35-5
Molecular Formula	C10H11N9O3
Molecular Weight	305.26 g/mol
Synonyms	8-Azido-2'-deoxyadenosine; 8-N3-2'-dA; 8-Azidodeoxyadenosine; 2'-Deoxy-8-azidoadenosine; 8-Azido-9-(2-deoxy-β-D-erythro-pentofuranosyl)adenine; 8-Azido-dA; N6-(8-Azido-2'-deoxyadenosine); Adenosine, 8-azido-2'-deoxy-
EINECS	Contact for details

Quality Control

Our 8-Azido-2'-Deoxyadenosine is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.