Description

1-(2-Azido-2-Deoxyarabinofuranosyl)Thymine is a specialized nucleoside analog, a key synthetic intermediate in the development of novel antiviral and anticancer agents. Its unique structure, featuring an azido group at the 2' position of the arabinofuranosyl sugar, is critical for probing enzyme mechanisms and constructing modified oligonucleotides. This high-purity compound is essential for pharmaceutical R&D, academic research in medicinal chemistry, and the synthesis of next-generation therapeutic nucleic acids.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel therapeutic agents targeting viral polymerases and reverse transcriptases.
• Biochemical Probe: Serves as a substrate or inhibitor in enzymatic studies to understand the mechanism of DNA/RNA polymerases and glycosylases.
• Oligonucleotide Synthesis: An intermediate for incorporating modified bases into oligonucleotides for antisense, siRNA, or diagnostic applications.
• Academic & Institutional Research: Fundamental research in bioorganic chemistry, chemical biology, and drug discovery pathways.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(2-Azido-2-Deoxyarabinofuranosyl)Thymine
CAS No.	131232-94-5
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	2'-Azido-2'-deoxyarabinothymine; 2'-Azido-2'-deoxy-1-β-D-arabinofuranosylthymine; 1-(2-Azido-2-deoxy-β-D-arabinofuranosyl)-5-methyluracil; 2'-N3-araT; Azidothymidine arabinoside analog; AraT Azido derivative; Thymine arabinoside 2'-azido analog
EINECS	Contact for details

Quality Control

Our 1-(2-Azido-2-Deoxyarabinofuranosyl)Thymine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.