Description

Doxorubicin-n-4-Hydroxyphenoxyacetamide CAS NO 131089-08-2 is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel prodrugs and targeted cancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in advanced oncology drug discovery and the development of antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel doxorubicin prodrugs designed for targeted drug delivery.
• Antibody-Drug Conjugate (ADC) Payload Synthesis: Used in the research and development of next-generation ADCs, where the modified structure allows for specific linker attachment.
• Oncology Research: Serves as a critical reagent in academic and industrial labs studying structure-activity relationships (SAR) of anthracycline derivatives.
• Preclinical Drug Development: Employed in the formulation and testing of new chemotherapeutic agents in non-clinical studies.
• Fine Chemical Synthesis: Used as a specialized intermediate in multi-step organic synthesis for complex molecule construction.

Basic Information

Product Name	Doxorubicin-n-4-Hydroxyphenoxyacetamide
CAS No.	131089-08-2
Molecular Formula	C₃₂H₃₃NO₁₄
Molecular Weight	655.60 g/mol
Synonyms	N-(4-Hydroxyphenoxyacetyl)doxorubicin; Doxorubicin 14-O-(4-hydroxyphenoxy)acetate; Doxorubicin-14-(4-hydroxyphenoxy)acetamide; 14-O-(4-Hydroxyphenoxyacetyl)doxorubicin; AD 198 derivative; Doxorubicin hydroxyphenoxyacetamide; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-(4-hydroxyphenoxy)acetate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates to ensure traceability and reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize condensation and exposure to moisture. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.