Description

(2R,3R,4S,5S)-2-(6-Aminopurin-9-Yl)-5-(Difluoromethyl)Oxolane-3,4-Diol is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate and a potential active pharmaceutical ingredient (API) in novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of antiviral and anticancer drugs, where precise stereochemistry and purity are critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and mechanisms of action.
• Antiviral Drug Development: A key precursor in the research and development of next-generation therapeutics targeting viral polymerases.
• Oncology Research: Investigated for its potential incorporation into prodrugs or as a direct chemotherapeutic agent targeting DNA/RNA synthesis in cancer cells.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of specialty active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(2R,3R,4S,5S)-2-(6-Aminopurin-9-Yl)-5-(Difluoromethyl)Oxolane-3,4-Diol
CAS No.	131077-98-0
Molecular Formula	C10H11F2N5O4
Molecular Weight	303.22 g/mol
Synonyms	2'-Deoxy-2'-difluoroguanosine; 2'-Difluoroguanosine; 9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(difluoromethyl)tetrahydrofuran-2-yl]guanine; 2'-Deoxy-2',2'-difluoroguanosine; Guanosine, 2'-deoxy-2',2'-difluoro-; DFG; 2'-Difluoro-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our (2R,3R,4S,5S)-2-(6-Aminopurin-9-Yl)-5-(Difluoromethyl)Oxolane-3,4-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.