Description

(S)-(+)-1-(1-Naphthyl)Ethyl Isothiocyanate is a high-purity chiral building block and derivatization agent of significant importance in asymmetric synthesis and analytical chemistry. Its value lies in its ability to introduce the 1-(1-naphthyl)ethyl chiral auxiliary, which is crucial for creating enantiomerically pure compounds and for chiral resolution via diastereomeric salt formation. This compound is essential for research and development laboratories in the pharmaceutical, agrochemical, and advanced materials sectors, where precise stereochemical control is paramount. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for critical applications.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to introduce chirality in the synthesis of enantiomerically pure pharmaceuticals, agrochemicals, and natural products.
• Derivatizing Agent for Chiral Resolution: Reacts with racemic mixtures of amines or alcohols to form diastereomers for separation via crystallization or chromatography.
• Intermediate for Liquid Crystal Materials: Serves as a key precursor in the synthesis of chiral dopants and components for liquid crystal displays (LCDs).
• Ligand Synthesis for Catalysis: Used in the preparation of chiral ligands for transition metal catalysts employed in enantioselective reactions.
• Analytical Chemistry Standard: Acts as a reference standard and derivatization reagent in HPLC and GC methods for enantiomeric purity analysis.
• Research & Development: A vital tool in academic and industrial R&D for exploring new stereoselective synthetic pathways.

Basic Information

Item	Details
Product Name	(S)-(+)-1-(1-Naphthyl)Ethyl Isothiocyanate
CAS No.	131074-55-0
Molecular Formula	C₁₃H₁₃NS
Molecular Weight	215.31 g/mol
Synonyms	(S)-1-(1-Naphthyl)ethyl isothiocyanate; (S)-(+)-1-(1-Naphthyl)ethyl isothiocyanate; (S)-1-(Naphthalen-1-yl)ethyl isothiocyanate; (S)-NEIT; (S)-1-(1-Naphthyl)ethyl mustard oil; (S)-α-Methyl-1-naphthalenemethyl isothiocyanate; (1S)-1-(1-Naphthyl)ethyl isothiocyanate; (S)-(-)-1-(1-Naphthyl)ethyl isothiocyanate (Note: Verify specific rotation sign with supplier)
EINECS	Contact for details

Quality Control

Every batch of (S)-(+)-1-(1-Naphthyl)Ethyl Isothiocyanate is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and process development standards. A comprehensive Certificate of Analysis (COA) detailing purity, specific rotation, and identity is provided with each shipment to guarantee reliable performance in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to pale yellow crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation ([α]D20)	Contact for details
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.