Description

3,4-Difluorothioanisole is a high-purity fluorinated aromatic thioether building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise molecular modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce sulfur and fluorine functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the production of next-generation herbicides and fungicides that leverage fluorine atoms for enhanced bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and liquid crystals with tailored electronic and optical properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of biological molecules for metabolic pathway studies and imaging.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific difluorothioanisole motifs.

Basic Information

Product Name	3,4-Difluorothioanisole
CAS No.	130922-41-7
Molecular Formula	C7H6F2S
Molecular Weight	160.18 g/mol
Synonyms	1,2-Difluoro-4-(methylthio)benzene; 3,4-Difluorophenyl Methyl Sulfide; Methyl 3,4-Difluorophenyl Sulfide; 3,4-Difluoro Thioanisole; 4-(Methylthio)-1,2-difluorobenzene; 1-(Methylthio)-3,4-difluorobenzene; 3,4-DFTA
EINECS	Contact for details

Quality Control

Our 3,4-Difluorothioanisole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements of advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flame. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.