Description

2-Piperidinecarbonyl Chloride (9Ci) is a versatile and highly reactive acid chloride derivative of pipecolic acid, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the piperidinecarbonyl moiety, a privileged scaffold in medicinal chemistry, into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for constructing complex heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of piperidine-containing drug candidates, including potential central nervous system (CNS) agents, analgesics, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the piperidine structure confers specific biological activity.
• Peptidomimetics & PROTACs: Employed in the construction of peptide analogs (peptidomimetics) and Proteolysis-Targeting Chimeras (PROTACs) for drug discovery programs.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialized polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Useful for synthesizing activity-based probes and affinity labels to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial quantities for research.

Basic Information

Product Name	2-Piperidinecarbonyl Chloride (9Ci)
CAS No.	130606-00-7
Molecular Formula	C6H10ClNO
Molecular Weight	147.60 g/mol
Synonyms	Piperidine-2-carbonyl chloride; 2-Piperidinecarboxylic acid chloride; L-Pipecolyl chloride; 2-Chlorocarbonylpiperidine; Pipecolinoyl chloride; (Piperidin-2-yl)methanoyl chloride; 2-Piperidylcarbonyl chloride; Homopipecolyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Piperidinecarbonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to maximize shelf life and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.