Description

Chlorambucil-Docosahexaenoic Acid Conjugate is a targeted prodrug designed to enhance the therapeutic index of the classic alkylating agent chlorambucil. This innovative conjugate leverages the tumor-targeting properties of the ω-3 fatty acid DHA to potentially improve drug delivery to cancer cells while minimizing systemic toxicity. It is a critical research-grade compound for pharmaceutical R&D teams focused on developing novel oncology therapeutics, particularly for hematological malignancies and solid tumors.

Application

• Oncology Research & Drug Development: Primary use as a lead compound in the development of targeted chemotherapy agents.
• Mechanistic Studies: Investigating the role of fatty acid transport mechanisms in enhancing cellular uptake of chemotherapeutics.
• Preclinical Evaluation: In vitro and in vivo studies to assess efficacy, pharmacokinetics, and biodistribution in various cancer models.
• Formulation Science: Development of novel drug delivery systems, such as liposomes or nanoparticles, incorporating this conjugate.
• Bioconjugate Chemistry: Serving as a reference standard or model compound for synthesizing other drug-biomolecule conjugates.
• Apoptosis & Cell Signaling Pathways: Tool for studying the induction of programmed cell death in cancer cell lines.

Basic Information

Product Name	Chlorambucil-Docosahexaenoic Acid Conjugate
CAS No.	130388-13-5
Molecular Formula	C34H51Cl2NO4
Molecular Weight	608.68 g/mol
Synonyms	DHA-Chlorambucil Conjugate; Chlorambucil-DHA; 4-[Bis(2-chloroethyl)amino]benzenebutanoic Acid Docosahexaenoic Acid Ester; Docosahexaenoyl Chlorambucil; DHA-Linked Chlorambucil; Chlorambucil ω-3 Conjugate; Anticancer Prodrug DHA-Chlorambucil
EINECS	Contact for details

Quality Control

Our Chlorambucil-Docosahexaenoic Acid Conjugate is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for advanced research applications. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analyses is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the material should be handled in a controlled, dry environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.