Description

Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, cis- (9Ci) is a high-purity, fluorinated cyclopropane derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique cis-configured, halogenated cyclopropane structure, which is essential for introducing conformational rigidity and specific stereochemistry into target molecules. Pharmaceutical and agrochemical researchers need it for the development of novel active ingredients, particularly where the cyclopropane motif is leveraged for metabolic stability and bioactivity. Its role is pivotal in medicinal chemistry for creating potent candidates in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel small-molecule drugs, especially protease inhibitors and receptor modulators.
• Agrochemical Active Ingredient Development: Used in constructing advanced herbicides and pesticides with enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals requiring fluorinated cyclopropane units.
• Medicinal Chemistry & SAR Studies: Integral for structure-activity relationship (SAR) exploration due to its defined stereochemistry and halogen atoms.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of complex, tailor-made molecules for client projects.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and the study of fluorine's effects on molecular properties.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, cis- (9Ci)
CAS No.	130340-16-8
Molecular Formula	C5H5Cl2FO
Molecular Weight	170.99 g/mol
Synonyms	cis-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride; (1R,2S)-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride; 2-Chloro-2-fluoro-1-methylcyclopropanecarboxylic acid chloride, cis-; 1-Methyl-2-chloro-2-fluorocyclopropanecarbonyl chloride; Fluorinated cyclopropane carbonyl chloride; Cyclopropanecarboxylic acid, 2-chloro-2-fluoro-1-methyl-, chloride, cis-; (1S,2R)-rel-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, cis- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Production adheres to cGMP guidelines where applicable, and comprehensive analytical testing is performed using HPLC, GC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.