Description

Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, cis- (9Ci) is a high-purity, reactive organofluorine building block essential for advanced chemical synthesis. Its unique cis-configured cyclopropane ring fused with halogenated acyl chloride functionality makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries to introduce the valuable 2-chloro-2-fluorocyclopropane moiety into target molecules, enabling the exploration of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing strained, halogenated cyclopropane rings known to modulate biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclopropane structure can enhance product efficacy and environmental profile.
• Material Science Research: Acts as a precursor for specialty monomers or ligands in the development of novel polymers and advanced materials with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for complex molecule construction, including natural product synthesis and methodology development, leveraging its high reactivity.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the effects of geminal chloro-fluoro substitution on molecular conformation and reactivity.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, cis- (9Ci)
CAS No.	130340-15-7
Molecular Formula	C4H3Cl2FO
Molecular Weight	156.97 g/mol
Synonyms	cis-2-Chloro-2-fluorocyclopropanecarbonyl chloride; (1R,2S)-2-Chloro-2-fluorocyclopropane-1-carbonyl chloride; (1S,2R)-2-Chloro-2-fluorocyclopropane-1-carbonyl chloride; 2-Chloro-2-fluorocyclopropanecarboxylic acid chloride; 2-Chloro-2-fluorocyclopropanecarbonyl chloride; 2-Fluoro-2-chlorocyclopropanecarboxylic acid chloride; 2-Fluoro-2-chlorocyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, cis- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including assay by GC or HPLC, identity confirmation (IR, NMR), and control of key impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at recommended temperatures (typically 2-8°C or as specified on the label). This compound is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.