Description

Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, trans- (9Ci) is a high-purity, chiral fluorinated building block essential for advanced organic synthesis. This compound matters because its unique cyclopropane and acid chloride functionalities enable the precise introduction of complex, sterically defined molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated cyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of monomers or functional additives for specialty polymers with tailored properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, trans- (9Ci)
CAS No.	130340-07-7
Molecular Formula	C5H5Cl2FO
Molecular Weight	170.99 g/mol
Synonyms	trans-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride; (1R,2S)-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride; (1S,2R)-2-Chloro-2-fluoro-1-methylcyclopropanecarbonyl chloride; 2-Chloro-2-fluoro-1-methylcyclopropanecarboxylic acid chloride; 1-Methyl-2-chloro-2-fluorocyclopropanecarbonyl chloride; Fluorinated cyclopropane carbonyl chloride; Chiral fluorocyclopropane building block
EINECS	Contact for details

Quality Control

Every batch of our Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-1-Methyl-, trans- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet the stringent requirements of process chemistry and GMP starting material guidelines. Our quality management system is designed to guarantee batch-to-batch consistency and traceability. Comprehensive Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.