Description

Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, trans- (9Ci) is a high-value, multifunctional fluorinated building block essential for advanced organic synthesis. Its unique trans-configured cyclopropane ring, combined with reactive acyl chloride and halogen substituents, makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its structure enables the introduction of key pharmacophores and modulates physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in antiviral, anticancer, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclopropane moiety enhances bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers with unique thermal and chemical resistance properties.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organometallic catalysts for asymmetric synthesis applications.
• Fluorine Chemistry Research: A versatile substrate for studying nucleophilic substitution reactions and exploring new fluorination methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches under cGMP guidelines.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, trans- (9Ci)
CAS No.	130340-06-6
Molecular Formula	C4H3Cl2FO
Molecular Weight	156.97 g/mol
Synonyms	trans-2-Chloro-2-fluorocyclopropanecarbonyl chloride; (1R,2S)-2-Chloro-2-fluorocyclopropane-1-carbonyl chloride; (1S,2R)-2-Chloro-2-fluorocyclopropane-1-carbonyl chloride; 2-Chloro-2-fluorocyclopropanecarboxylic acid chloride; 2-Chloro-2-fluorocyclopropanecarbonyl chloride; 2-Fluoro-2-chlorocyclopropanecarboxylic acid chloride; 2-Fluoro-2-chlorocyclopropanecarbonyl chloride; NSC 405124
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 2-Chloro-2-Fluoro-, trans- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by GC/HPLC), isomeric purity, and impurity profiles. Our quality commitment supports compliance with relevant guidelines for use in research and development under cGMP-like conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (trans-)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.