Description

Adenosine 3',5'-Cyclic Methylphosphonothioate is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed for enhanced stability and biological activity. This compound is a critical research tool for investigating intracellular signaling pathways mediated by cAMP-dependent protein kinases (PKA) and other cAMP effectors. It is primarily utilized by researchers and developers in the pharmaceutical and life sciences sectors for studying cellular physiology, drug discovery, and signal transduction mechanisms.

Application

• Biochemical Research: Acts as a potent and stable activator of Protein Kinase A (PKA) for in vitro and cell-based studies.
• Signal Transduction Studies: Used to elucidate the role of cAMP in cellular processes such as metabolism, gene expression, and ion channel regulation.
• Drug Discovery & Screening: Serves as a reference compound or positive control in high-throughput screening assays targeting cAMP pathways.
• Neuroscience Research: Investigates cAMP's function in neuronal plasticity, memory formation, and neurotransmitter release.
• Cardiovascular Research: Explores the modulation of heart muscle contractility and vascular tone via cAMP signaling.
• Metabolic Disorder Studies: Used in research on diabetes and obesity to understand hormonal regulation of glucose and lipid metabolism.

Basic Information

Product Name	Adenosine 3',5'-Cyclic Methylphosphonothioate
CAS No.	130320-50-2
Molecular Formula	C11H14N5O5PS
Molecular Weight	367.30 g/mol
Synonyms	8-(Methylthio)-cAMP; 8-Methylthioadenosine 3',5'-cyclic monophosphate; 8-Methylthio-cAMP; Rp-8-Methylthio-cAMPS; Rp-8-Methylthio-cyclic adenosine monophosphate; Adenosine cyclic 3',5'-(methylphosphorothioate); Rp isomer
EINECS	Contact for details

Quality Control

Our Adenosine 3',5'-Cyclic Methylphosphonothioate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.