Description

1,4-Anhydro-2-Deoxy-3-o-[(tert-Butyl)Diphenylsilyl]-D-Erythro-Pent-1-Enitol is a sophisticated, high-purity chemical intermediate featuring a protected silyl ether group, which is critical for selective deprotection strategies in complex organic syntheses. This compound is valued for its role as a key chiral building block, enabling the precise construction of complex molecular architectures with defined stereochemistry. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside analogs, antiviral agents, and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer research.
• Organic Synthesis Building Block: Used in the preparation of complex carbohydrates, glycomimetics, and other biologically active molecules requiring stereospecific protection and deprotection steps.
• Process Chemistry: Employed in scale-up and route development for Active Pharmaceutical Ingredients (APIs) where the tert-butyldiphenylsilyl (TBDPS) protecting group is essential.
• Academic & R&D Laboratories: Serves as a valuable reagent for methodological studies in synthetic organic chemistry, particularly in carbohydrate and heterocycle chemistry.
• Probe & Diagnostic Development: Potential use in creating labeled probes or molecular scaffolds for biochemical and diagnostic applications.

Basic Information

Item	Details
Product Name	1,4-Anhydro-2-Deoxy-3-o-[(tert-Butyl)Diphenylsilyl]-D-Erythro-Pent-1-Enitol
CAS No.	130277-32-6
Molecular Formula	C21H26O3Si
Molecular Weight	354.52 g/mol
Synonyms	1,4-Anhydro-2-deoxy-3-O-[(1,1-dimethylethyl)diphenylsilyl]-D-erythro-pent-1-enitol; 3-O-(tert-Butyldiphenylsilyl)-1,4-anhydro-2-deoxy-D-erythro-pent-1-enitol; TBDPS-protected 1,4-anhydropentitol derivative; 1,4-Anhydro-2-deoxy-3-O-TBDPS-D-erythro-pent-1-enitol; 2-Deoxy-3-O-(tert-butyldiphenylsilyl)-1,4-anhydro-D-erythro-pent-1-enitol
EINECS	Contact for details

Quality Control

Our 1,4-Anhydro-2-Deoxy-3-o-[(tert-Butyl)Diphenylsilyl]-D-Erythro-Pent-1-Enitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong bases and should be kept away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.