Description

3-Oxocyclobutanecarbonyl Chloride is a highly reactive and versatile acid chloride derivative of 3-oxocyclobutanecarboxylic acid. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the 3-oxocyclobutane moiety into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex cyclic frameworks and novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those containing constrained cyclobutane rings for improved metabolic stability and potency.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with unique modes of action.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials with tailored thermal or optical properties.
• Peptide Mimetics: Facilitates the construction of conformationally restricted peptide analogs for biochemical research and therapeutic discovery.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in various metal-catalyzed reactions to form carbon-carbon bonds.
• Academic & R&D Laboratories: Essential reagent for methodological development and exploring new reaction pathways in synthetic organic chemistry.

Basic Information

Product Name	3-Oxocyclobutanecarbonyl Chloride
CAS No.	130233-77-1
Molecular Formula	C5H5ClO2
Molecular Weight	132.54 g/mol
Synonyms	3-Oxocyclobutanecarboxylic Acid Chloride; Cyclobutanone-3-carbonyl Chloride; 3-Oxocyclobutane-1-carbonyl Chloride; 1-(Chlorocarbonyl)cyclobutan-3-one; 3-Ketocyclobutanecarbonyl Chloride; Oxetan-3-one-1-carbonyl chloride (tautomeric form); 130233-77-1
EINECS	Contact for details

Quality Control

Every batch of 3-Oxocyclobutanecarbonyl Chloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including NMR, HPLC, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.