Description

10-Aminocamptothecin is a potent, water-soluble derivative of the natural alkaloid camptothecin, designed to enhance therapeutic efficacy and reduce toxicity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel anticancer therapies, primarily targeting DNA topoisomerase I. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology drug discovery and advanced formulation studies.

Application

• Anticancer Drug Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel chemotherapeutic agents.
• Biomedical Research: Used as a reference standard and tool compound in pharmacological studies to investigate topoisomerase I inhibition mechanisms.
• Preclinical Studies: Essential for in vitro and in vivo efficacy and toxicity testing of new oncology drug candidates.
• Pharmaceutical Formulation: Employed in the research and development of injectable formulations and targeted drug delivery systems.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and enzyme inhibition assays to discover new therapeutic leads.

Basic Information

Product Name	10-Aminocamptothecin
CAS No.	130194-90-0
Molecular Formula	C20H17N3O4
Molecular Weight	363.37 g/mol
Synonyms	10-APT; 10-Amino-CPT; (S)-10-Aminocamptothecin; 10-Amino-20(S)-camptothecin; 4-Ethyl-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC 603071; Camptothecin, 10-amino-
EINECS	Contact for details

Quality Control

Our 10-Aminocamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to greenish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.