Description

5'-O-(4,4'-Dimethoxytrityl)-N4-Isobutyryl-2'-Deoxycytidine-3'-O-Succinic Acid is a critical, high-purity phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound matters because it serves as a precisely protected building block, enabling the automated and reliable production of DNA sequences for research and therapeutic applications. It is essential for biotechnology, pharmaceutical, and diagnostic companies engaged in the development of antisense oligonucleotides, primers, probes, and other synthetic nucleic acids.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of active pharmaceutical ingredients (APIs) for antisense, siRNA, and aptamer-based drugs.
• Diagnostic Probe Development: Synthesis of labeled or unlabeled DNA probes for genetic testing and molecular diagnostics.
• Research-Grade Primer Synthesis: Manufacture of primers for PCR, sequencing, and other molecular biology techniques.
• Gene Synthesis Services: A fundamental raw material for companies offering custom gene and fragment synthesis.
• Development of Nucleic Acid Libraries: For high-throughput screening applications in drug discovery.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-N4-Isobutyryl-2'-Deoxycytidine-3'-O-Succinic Acid
CAS No.	130150-82-2
Molecular Formula	C41H43N3O11
Molecular Weight	753.80 g/mol
Synonyms	dC(Ibu) Phosphoramidite Succinate; 5'-DMT-N4-Isobutyryl-2'-deoxycytidine-3'-succinate; N4-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-succinic Acid; dC(Ibu) CE Phosphoramidite; dC(ib) Succinyl CPG Precursor; 2'-Deoxycytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N4-(2-methyl-1-oxopropyl)-, 3'-(hydrogen succinate); CAS 130150-82-2
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-N4-Isobutyryl-2'-Deoxycytidine-3'-O-Succinic Acid is manufactured under strict quality systems to ensure it meets the exacting standards required for oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee reproducible performance and supply chain reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and reactivity. For long-term storage, desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.